Emily Hollenbeck experienced a profound and persistent depression that she compared to a black hole, where she felt weighed down and immobilized by the gravity of her emotions. Knowing the deadly consequences of the illness, given that both of her parents had died by suicide, Hollenbeck decided to explore a radical solution: undergoing deep brain stimulation (DBS) as part of an experimental therapy. Researchers believe that DBS could offer hope to the millions of Americans who suffer from treatment-resistant depression. While the treatment is currently approved for conditions like Parkinson’s disease and epilepsy, there is optimism that it will soon be more widely available for depression.
DBS involves the implantation of electrodes in specific regions of the brain, delivering targeted electrical impulses similar to a pacemaker for the brain. Despite some setbacks in large studies, recent research has shown promising results, with ongoing efforts to tailor treatments to individual patients. Hollenbeck underwent DBS surgery at Mount Sinai West, where thin metal electrodes were placed in her brain to regulate emotional behavior and alleviate feelings of sadness.
The immediate effects of DBS were life-changing for Hollenbeck, who experienced a lifting of her negative mood and a renewed sense of enjoyment in everyday activities. She found pleasure in music again and felt a newfound buoyancy in her daily life. While DBS is not a cure-all and she still requires medication and ongoing care, Hollenbeck is grateful for the progress she has made.
As researchers continue to study the effectiveness of DBS for depression, advancements are being made in tracking patients’ progress and adjusting treatments accordingly. Hollenbeck participates in remote monitoring and visits Mount Sinai’s research lab to provide data on her recovery process. By combining brain recordings with other information, doctors can make informed decisions about adjusting the treatment to best support each patient.
While some doctors remain skeptical of DBS for depression due to potential complications and the complexity of the brain mechanisms involved, ongoing research and clinical trials offer hope for the future of this innovative therapy. Hollenbeck’s journey with DBS serves as a testament to the transformative impact it can have on individuals battling treatment-resistant depression.
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